Richard S. Nicholas

This study shows that aging impairs microglial function in demyelination and remyelination, but microglia replacement can restore these processes in aged mice.

This paper introduces a multimodal foundation model for predicting protein phenotypes using sequence, structure, and natural language, showing competitive performance and novel insights into disease-related proteins.

This study shows that inhibiting S1P signaling with FTY720 suppresses Th1-like Treg generation and restores their suppressive function by reversing mitochondrial uncoupling.

The paper applies multivariate mechanistic models to a clinical trial in multiple sclerosis to investigate pathways linking simvastatin to clinical outcomes.

This study finds that multiple sclerosis accelerates brain ageing, with older-appearing brains linked to faster disability progression.