Owain W. Howell

This study shows that aging impairs microglial function in demyelination and remyelination, but microglia replacement can restore these processes in aged mice.

The paper uses spatial transcriptomics to analyze inflammation in multiple sclerosis, identifying unique immune signatures in tertiary lymphoid-like structures.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

The paper shows that neuroinflammation in MS brains causes structural changes at the node of Ranvier, leading to axonal conduction failure.

The paper shows that elevated circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is associated with reduced AG:UAG ratio in Parkinson’s disease dementia patients.

The paper develops a mass spectrometry imaging method to map sterol distributions in mouse brain tissue, revealing spatial cholesterol metabolism patterns in wild-type and cholesterol 24S-hydroxylase knock-out mice.