Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease
Alexandra D. Steigmeyer, Alexandria S. Battison, Iris R. Liebman, Christopher H. van Dyck, Barbara Stauch Slusher, Amy F.T. Arnsten, Stacy Alyse Malaker, Dibyadeep Datta
This study uses proteomic analysis in aged rhesus macaques to show that GCPII inhibition alters region-specific protein expression patterns linked to Alzheimer's disease pathology.
Acta Neuropathologica Communications · Oct 3, 2026Peer-reviewedNeuroscience