Amy F.T. Arnsten

This study uses proteomic analysis in aged rhesus macaques to show that GCPII inhibition alters region-specific protein expression patterns linked to Alzheimer's disease pathology.

This study identifies a lipid signaling mechanism involving AEA-Gpr12 in thalamus that extends working memory duration by suppressing cAMP and supporting sustained neural activity in PFC.

The paper shows that aging macaques lose calbindin and gain pT217-tau in prefrontal cortical dendrites, linking calbindin loss to increased tau pathology and AD risk.

This paper compares working memory models in macaques and marmosets using connectomic data, finding differences in distractibility and showing that model outcomes can be swapped by adjusting circuit parameters.

The paper compares distractibility between marmosets and macaques in cognitive tasks and links it to dopamine D1 receptor expression in prefrontal parvalbumin neurons.

This study identifies age-related calcium signaling dysregulation in macaque entorhinal cortex linked to early tau hyperphosphorylation, suggesting a mechanism for Alzheimer's disease initiation.

This study compares extrasynaptic and synaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices using immunoelectron microscopy, finding higher extrasynaptic expression in subgenual cortex and higher synaptic expression in dorsolateral prefrontal cortex.

This study shows that kynurenic acid (KYNA) and its enzyme KAT II expand in primate dlPFC, impairing cognitive functions by affecting NMDA and nic-7Rs, and suggests targeting KYNA as a therapeutic approach for neuroinflammatory disorders.

The paper examines pT217-tau localization in aged rhesus macaques, showing its aggregation on microtubules and trafficking between neurons, supporting its role as a fluid biomarker for early neurodegeneration.

This study shows that HCN and Slack channels interact in PFC pyramidal neurons to regulate excitability and working memory through a complex that suppresses neuronal firing.