Christopher H. van Dyck

This study uses proteomic analysis in aged rhesus macaques to show that GCPII inhibition alters region-specific protein expression patterns linked to Alzheimer's disease pathology.

This study finds that nucleus basalis of Meynert (Ch4) volume is inversely associated with cortical amyloid burden in cognitively unimpaired adults at varying genetic risk for Alzheimer's disease.

This paper investigates how APOEe4 influences molecular changes in Alzheimer's disease through proteomic, epigenetic, and genetic analyses of post-mortem brain samples, identifying key proteins and epigenetic markers associated with risk and resilience.

This study evaluates an alternative reference region method for [11C]UCB-J to improve test-retest reliability and Parkinson's disease detection, finding reduced variability and greater effect sizes with a 10mL white matter reference region.

The paper examines the relationship between SV2A PET imaging and CSF synaptic protein levels in Alzheimer's disease patients and cognitively normal individuals, finding associations between lower synaptic density and specific protein markers.

This study uses PET imaging to show a strong positive correlation between mGluR5 and synaptic density in early AD patients and cognitively normal individuals, suggesting mGluR5 may mediate early synaptic loss in AD.

This study investigates sex differences in the genetic pleiotropy between hearing difficulty and brain imaging-derived phenotypes using large-scale GWAS data and multiple analytical methods.

The paper examines pT217-tau localization in aged rhesus macaques, showing its aggregation on microtubules and trafficking between neurons, supporting its role as a fluid biomarker for early neurodegeneration.

The paper develops PCBrainAge, an epigenetic age predictor for brain tissue, showing it better captures aging heterogeneity and links to Alzheimer's disease features than existing methods.

The paper identifies shared genetic loci between telomere length and brain morphology, and finds regulatory gene associations in brain transcriptomic and epigenomic profiles.