Multi-scale model suggests the trade-off between protein and ATP demand as a driver of metabolic changes during yeast replicative ageing
Barbara Schnitzer, Linnea Österberg, Iro Skopa, Marija Cvijović
The paper develops a multi-scale model of yeast replicative ageing, identifying metabolic phases and interventions that influence lifespan by linking protein damage and ATP demand.
PLoS Computational Biology · Jul 7, 2022Peer-reviewedSystems Biology