Linnea Österberg

The choice of the objective function in flux balance analysis is crucial for predicting replicative lifespans in yeast

This study shows that choosing the right objective function in flux balance analysis improves predictions of replicative lifespan in yeast.

Multi-scale model suggests the trade-off between protein and ATP demand as a driver of metabolic changes during yeast replicative ageing

The paper develops a multi-scale model of yeast replicative ageing, identifying metabolic phases and interventions that influence lifespan by linking protein damage and ATP demand.

A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism

The paper develops a hybrid modeling framework integrating Boolean and enzyme-constrained networks to study the interplay between nutrient signaling and metabolism in yeast, revealing new insights into their regulatory effects.