Barbara Schnitzer

This study shows that choosing the right objective function in flux balance analysis improves predictions of replicative lifespan in yeast.

The paper develops a multi-scale model of yeast replicative ageing, identifying metabolic phases and interventions that influence lifespan by linking protein damage and ATP demand.

The paper shows that damage retention and early repair in yeast promote rejuvenation and longer healthy lifespans by reducing damage variability and stress susceptibility.