Low-heteroplasmy mitochondrial DNA mutations improve clonal reconstruction of human cells
Chen Weng, Teng Gao, William N. Colgan, Isaac Johnson, Jonas A. Gudera, Michael Poeschla, Jonathan S. Weissman, Vijay G. Sankaran
This study shows that low-heteroplasmy mitochondrial DNA mutations provide reliable clonal information, improving clonal reconstruction in human cells.
bioRxiv · Aug 21, 2026 · PreprintGenomics