Jonas A. Gudera

Low-heteroplasmy mitochondrial DNA mutations improve clonal reconstruction of human cells

This study shows that low-heteroplasmy mitochondrial DNA mutations provide reliable clonal information, improving clonal reconstruction in human cells.

Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans

MitoDrift models mitochondrial inheritance to enable high-precision lineage tracing in human tissues, revealing clonal dynamics and linking them to transcriptional and epigenetic programs.

DPP9 deficiency: an inflammasomopathy which can be rescued by lowering NLRP1/IL-1 signaling

This study identifies DPP9 deficiency as a Mendelian disorder causing inflammasome hyperactivity, which can be rescued by reducing NLRP1/IL-1 signaling in mice.