Leonard Ira Zon

This study identifies CHKA/PAF metabolic dependency in clonal hematopoiesis across multiple mutations and shows its suppression reduces clonal expansion.

The paper identifies a novel de novo GABPA variant in a patient with unclassified vascular tumors, linking it to disrupted vascular development through structural and functional analyses.

MitoDrift models mitochondrial inheritance to enable high-precision lineage tracing in human tissues, revealing clonal dynamics and linking them to transcriptional and epigenetic programs.

This study identifies RAPGEF1 as a gene modulating melanoma and nevi risk through RAS activation, using fine-mapping, expression data, and functional assays.

The paper identifies crater-shaped structures in melanoma that enhance immune response to checkpoint blockade therapy in humans and zebrafish.

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

This study shows that swimming motions in larval zebrafish trigger Ca2+ events in vascular endothelial cells through mechanical activation of Piezo1, independent of neural activity or blood flow.

This study shows that RNA methylation, specifically m6A, regulates stress granule formation and function during erythropoiesis by modulating ATXN2 expression and RNA translation.

The paper identifies a BMP-dependent attractor state in melanoma precursor cells that precedes neural crest fate and is associated with ID1 expression in human melanoma.

The paper shows that leukemia cells secrete apelin, which promotes clonal expansion of niche endothelial cells and drives leukemogenesis in zebrafish.

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

The paper identifies RNA-binding as a common feature of transcription factors, showing it contributes to gene regulation and is conserved in vertebrates.

This study identifies transcription factors that induce vascular blood stem cell niches in vivo, enabling synthetic niche generation and potential therapeutic applications.

The paper identifies structural differences in zebrafish α4 chain of type IV collagen and shows its conserved anti-angiogenic activity compared to humans.

The paper shows that macrophages interact with nascent blood stem cells in zebrafish embryos, influencing their survival and clonality through mechanisms involving calreticulin.

The paper identifies how dmPGE2 regulates inflammatory gene activation in HSPCs by modulating enhancer chromatin structure through H2A.Z-variant nucleosome retention and acetylation.

The paper identifies six HSC states and shows niche perturbations induce rapid transitions between them, revealing HSC-specific molecular signatures and chromatin features related to regenerative potential.

The paper uses deep learning to analyze enhancer logic across species in melanoma, identifying conserved regulatory complexes and their roles.

The paper identifies multiple melanoma susceptibility genes and variants by integrating MPRA with eQTL data, revealing MX2's role in melanoma promotion.

This study xenografts murine bone marrow cells into zebrafish embryos to study hematopoiesis and host-pathogen interactions, showing successful integration and immune response.

The paper identifies GPR132 as a specific receptor for certain oxylipins that enhance hematopoiesis in vertebrates, using bioinformatics and functional assays.

This study identifies DDX27 as a regulator of skeletal muscle growth and regeneration by modulating translational processes and ribosome biogenesis in zebrafish.