Pressure Points: Endothelial Responses to Shear Stress and Pressure in Health and Pulmonary Arterial Hypertension
Kellen Hirsch, Christian Mandrycky, Isabella Kwan, Hongyang Pi, William A. Altemeier, Tim Lahm, Peter J. Leary, Sina A. Gharib, Ying Yi Zheng, Samuel G. Rayner
This study examines how shear stress and pressure affect pulmonary arterial endothelial cells in health and PAH, revealing divergent transcriptional responses across disease states and donor sex.
bioRxiv · Jul 28, 2025 · PreprintBioengineering