Increasing plasma bile salt levels with Bulevirtide alleviates DSS-induced colitis and LPS-induced inflammation
Thuc-Anh Nguyen, Reinout L.P. Roscam Abbing, Pim J. Koelink, Joost M. Lambooij, Wietse In het Panhuis, Dirk Rudi de Waart, Isabelle Bolt, Suzanne Duijst, Esther W.M. Vogels, Ricky Siebeler, Menno P.J. de Winther, Bruno Guigas, Manon E. Wildenberg, Coen C. Paulusma, Stan F.J. van de Graaf
This study shows that Bulevirtide increases plasma bile salt levels in mice, reducing inflammation in LPS-induced models and DSS-induced colitis.
bioRxiv · Apr 23, 2026 · PreprintImmunology