Optogenetic Rescue Reveals Spatiotemporal Rules of Germ-Layer Patterning
Naomi J. Baxter, Robert A. Piscopio, Joseph Rufo, Dasol Han, Isobel Whitehead, Jasmine Dhillon, Siddharth S. Dey, Maxwell Z. Wilson
The paper uses optogenetics in human gastruloids to show that precise spatiotemporal WNT signaling controls germ-layer patterning.
bioRxiv · Dec 11, 2025 · PreprintDevelopmental Biology