Maxwell Z. Wilson

The paper shows that inhibitory Fc{gamma}RIIB limits macrophage signaling duration, while activating Fc receptors control sensitivity, using chimeric receptors and in silico modeling.

The paper develops an ISRGDF15 index to quantify the GDF15 arm of the ISR in human cells and tissues, showing its upregulation in specific tissues and correlation with age.

This study uses optogenetic ISR activation to show reduced glioblastoma invasion and migration, suggesting potential therapeutic strategies.

The paper identifies anti-resonance in Wnt signaling that suppresses mesoderm differentiation in human cells by analyzing signal frequency effects using optogenetics and modeling.

The paper uses optogenetics in human gastruloids to show that precise spatiotemporal WNT signaling controls germ-layer patterning.

scSTAMP-seq enables spatially resolved single-cell transcriptomics and epigenomics by using photolabile oligonucleotides and light gradients to capture cell positions before sequencing.

The paper creates an explainable map of human gastruloid morphospace to identify failure modes and predict teratogens using drug perturbations and mathematical modeling.

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

This study uses optogenetic control of the ISR to show proportional encoding of stress inputs and reveals a stress memory landscape through an ODE model.

This paper presents a scalable, easy-to-deploy protocol for detecting SARS-CoV-2 genetic material using Cas13-based technology paired with PCR and low-cost instrumentation.

PEARL is a fast, low-cost method for isolating RNA, DNA, and proteins to detect SARS-CoV-2 without commercial kits.

The paper identifies the proline-rich domain (PRD) of tau as a driver of liquid-liquid phase separation (LLPS) in cells, showing its phosphorylation-dependent behavior and interaction with microtubules.

The paper constructs synthetic immediate-early genes (synIEGs) to study signal-decoding circuits, demonstrating their ability to implement complex regulation and respond to combined stimuli.