Population-specific polygenic risk for Alzheimer's disease is associated with Mini-Mental State Examination-based cognitive decline in a Japanese cohort
Yutaro Yanagida, Yutaka Nakachi, Issei Morita, Naoto Kajitani, Minoru Takebayashi, Kazuhiro Yoshiura, Manabu Makinodan, Tempei Ikegame, Kiyoto Kasai, Miki Bundo, Kazuya Iwamoto
The paper examines the association between Alzheimer's disease polygenic risk scores and cognitive decline measured by MMSE in a Japanese cohort, finding stronger associations with scores derived from Japanese GWAS.
medRxiv · Mar 28, 2026 · PreprintGenetic & Genomic Medicine