Naoto Kajitani

This study shows that genetic and epigenetic regulation of SLC6A4 influences vulnerability to cognitive decline and depressive symptoms in older adults.

The paper examines the association between Alzheimer's disease polygenic risk scores and cognitive decline measured by MMSE in a Japanese cohort, finding stronger associations with scores derived from Japanese GWAS.

This study shows chronic social defeat stress in mice causes metabolic dysregulation through cerebellar pathways, linking psychological stress to type II diabetes.

The paper identifies TCF7L2 as a gene associated with antidepressant effects on hippocampal astrocytes in depression model mice.

This study identifies G protein-biased LPAR1 agonism as a mechanism underlying the antidepressant effects of TCAs like amitriptyline, distinguishing them from SSRIs.