Manabu Makinodan

This study shows that disrupting developmental myelination in the medial prefrontal cortex impairs adult social behavior and PV interneuron function in mice, with parallels in human schizophrenia.

This study shows that genetic and epigenetic regulation of SLC6A4 influences vulnerability to cognitive decline and depressive symptoms in older adults.

The paper examines the association between Alzheimer's disease polygenic risk scores and cognitive decline measured by MMSE in a Japanese cohort, finding stronger associations with scores derived from Japanese GWAS.

This study develops human brainstem organoids containing neural crest cells and various neuron types, validated by single-cell RNA sequencing, proteomics, and electrophysiology.