Cellular heterogeneity in the developing forebrain masks transcriptional outcomes and principles of Evf2 enhancer lncRNA-Dlx5/6UCE-gene guidance
Edward Li, Abhijit Chakraborty, Sara Kohtz, Ivelisse Cajigas, Fion Shiau, Robert J. Vassar, Brian S. Clark, Jhumku D. Kohtz
The paper uses single-cell transcriptomics to show Evf2 lncRNA guides Dlx5/6UCE to many enhancer-gene guidance sites, with subpopulation-specific effects and long-range gene regulation.
bioRxiv · Feb 20, 2024 · PreprintMolecular Biology