Hao Luo

This study uses multimodal spatial-omics to analyze papillary craniopharyngiomas, identifying tumor cell states and microenvironment interactions.

Ori-Finder-Arch improves oriC prediction in archaea with higher accuracy, speed, and scalability compared to its predecessor.

This paper introduces Ouroboros, a framework that improves drug discovery by integrating molecular representation learning with generative modeling, outperforming traditional methods in multiple tasks.

DeOri 10.0 is an updated database of eukaryotic replication origins with expanded datasets and annotations, providing reference replication origins across multiple species.

Ori-Finder 2022 updates its web server to predict bacterial replication origins with improved features and expanded functionality.

The paper analyzes metabolic responses to a mixed meal test in an obese cohort, linking tissue metabolism with gut microbiota changes and identifying potential biomarkers for T2DM.

The paper shows Evf2 RNA regulates gene expression in mouse forebrain by interacting with Sox2 to control enhancer interactions and chromosome topology.

This paper uses Bayesian modeling to identify temperature-dependent enzymes in yeast metabolism, revealing squalene epoxidase as a key rate-limiting enzyme and demonstrating its role in thermotolerance.

The paper develops a computational model using sequence information to predict human gene essentiality, achieving high AUC scores and identifying previously overlooked essential genes.