Fion Shiau

This study identifies the lncRNA Peanut as promoting rod photoreceptor differentiation and neurogenesis by inhibiting Notch signaling and regulating Tox2 expression in retinal progenitor cells.

The paper uses single-cell transcriptomics to show Evf2 lncRNA guides Dlx5/6UCE to many enhancer-gene guidance sites, with subpopulation-specific effects and long-range gene regulation.

This study shows that Atoh7 is essential for RGC survival but not for their specification, as RGCs can develop without Atoh7 when apoptosis is inhibited.

This study uses scRNA-Seq to analyze human and mouse retinal development, identifying conserved and species-specific gene expression patterns and a novel role for ATOH7 in photoreceptor specification.

The paper uses single-cell RNA sequencing to analyze retinal development stages and identifies NFI factors as regulators of late progenitor cell specification and mitotic exit.

The paper shows that Lhx2, with its coactivator Ldb1 and corepressor Rnf12, regulates the balance between neurogenesis and gliogenesis in the retina by controlling cell cycle exit, Notch signaling, and expression of neurogenic factors.