Pharmacology & ToxicologybioRxivPreprint
Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling
Aleksandra Judina, Zhiyao Shi, Jiarong Fu…·Julia Gorelik
This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.