Activation of the NAD⁺-Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation
Keiji Saito, Ryusuke Hosoda, Ryo Numazawa, Hori Tomoki, Iyori Nojima, Yukika Saga, Yuki Tatekoshi, Tatsuya Sato, Koki Abe, Atsushi Kuno
This study shows that chronic low-dose doxorubicin causes mitochondrial dysfunction and inflammation in renal tubules, which can be mitigated by activating the NAD⁺-Sirtuin axis with resveratrol or NMN.
bioRxiv · Aug 3, 2026 · PreprintPharmacology & Toxicology