Yuki Tatekoshi

This study shows that chronic low-dose doxorubicin causes mitochondrial dysfunction and inflammation in renal tubules, which can be mitigated by activating the NAD⁺-Sirtuin axis with resveratrol or NMN.

This study uses hiPSC-CMs to model inflammation-induced diastolic dysfunction in HIV patients and tests drug effects on calcium transient.

This study shows that SIRT2 inhibition reduces cardiac hypertrophy and heart failure in mice by modulating NRF2 activity and antioxidant defenses.