A plug-and-play ROI imaging module and deep-learning denoising framework extend three-photon microscopy to 1.7 mm depth
J H Su, Shoupei Liu, Shasha Yang, Yanfeng Zhu, Xinyang Gu, Yaoguang Zhao, Chenjie Li, Min Zhang, Antao Chen Antao Chen, H. B. Yu, Bo Li
This paper introduces a hardware and software solution that extends three-photon microscopy depth to 1.7 mm by improving signal-to-noise ratio and noise removal.
bioRxiv · Jan 8, 2026 · PreprintNeuroscience