Author

Yaoguang Zhao

Shanghai Jiao Tong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 4 Organism:mouse· 4 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Bo LiiD· 4 shared Shoupei Liu· 4 shared H. B. YuiD· 3 shared Xinyang GuiD· 3 shared Yanfeng Zhu· 3 shared Cihang KongiD· 2 shared Jiahao HuiD· 2 shared Jingchuan WuiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersNeuroscience

Bo LiORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Microglial pruning of extinction-ensemble synapses preserves fear memory

Yongling Wang, Yue Cao, Taohui Liu, Tian-Tian Shi, Yaoguang Zhao, Zhihao Jin, Xiaoyu Yang, S Y Wang, Jia-Ze Ruan, Fan Zhang, Wei-Ke Li, Yang He, Sheng-Jie Lin, Wenying Xu, Xin Yi, , Tian‐Le Xu

The paper shows microglia preserve fear memory by selectively pruning extinction-ensemble synapses through local signaling cues during memory retrieval.

bioRxiv · May 7, 2026 · PreprintNeuroscience

Structure-guided, physics-aware reconstruction expands scan-limited multiphoton imaging

Shoupei Liu, Yaoguang Zhao, Jiahao Hu, Zhu Y, H. B. Yu, Bo Li

SPARC improves temporal and spatial resolution in scan-limited multiphoton imaging by integrating denoising and deep upsampling with structural and physical constraints.

bioRxiv · Apr 23, 2026 · PreprintNeuroscience

Kilohertz-rate two-photon voltage imaging of population dynamics in vivo

Min Zhang, Shoupei Liu, Yaoguang Zhao, Yanfeng Zhu, Xinyang Gu, Cihang Kong, Jiahao Hu, H. B. Yu, Jingchuan Wu, Fang Xu, Liang Chen, Ying Qing Mao, Bo Li

This paper introduces HS2PM, a two-photon microscope that enables kilohertz-rate imaging of neuronal populations in vivo, revealing voltage dynamics and their role in sensory adaptation and population coding.

bioRxiv · Mar 27, 2026 · PreprintNeuroscience

A plug-and-play ROI imaging module and deep-learning denoising framework extend three-photon microscopy to 1.7 mm depth

J H Su, Shoupei Liu, Shasha Yang, Yanfeng Zhu, Xinyang Gu, Yaoguang Zhao, Chenjie Li, Min Zhang, Antao Chen Antao Chen, H. B. Yu, Bo Li

This paper introduces a hardware and software solution that extends three-photon microscopy depth to 1.7 mm by improving signal-to-noise ratio and noise removal.

bioRxiv · Jan 8, 2026 · PreprintNeuroscience

A Compact Two-Photon Module for Simultaneous Dual-Depth, Multi-Region in vivo Brain Imaging

Yaoguang Zhao, Xinyang Gu, Cihang Kong, Shoupei Liu, Yanfeng Zhu, Jixiong Su, Jingchuan Wu, Fang Xu, Liang Chen, Ying Qing Mao, Bo Li

This paper introduces a compact two-photon imaging module that enables simultaneous dual-depth, multi-region in vivo brain imaging, revealing context-dependent and depth-divergent neural activity patterns.

Laser & Photonics Review · Nov 28, 2025Peer-reviewedBioengineering