H. B. Yu

SPARC improves temporal and spatial resolution in scan-limited multiphoton imaging by integrating denoising and deep upsampling with structural and physical constraints.

This paper introduces HS2PM, a two-photon microscope that enables kilohertz-rate imaging of neuronal populations in vivo, revealing voltage dynamics and their role in sensory adaptation and population coding.

This paper introduces a hardware and software solution that extends three-photon microscopy depth to 1.7 mm by improving signal-to-noise ratio and noise removal.