Comparative analysis of PknB inhibitors for reactivity and toxicity
Nathan Wlodarchak, Jeff Beczkiewicz, Steven Seitz, Zhengqing Ye, John Feltenberger, J Muse Davis, Rob Striker
This study evaluates the reactivity and toxicity of a PknB inhibitor, YH-8, finding high reactivity with thiolating agents, toxicity in zebrafish, and limited activity against non-tubercular mycobacteria.
bioRxiv · Sep 20, 2018 · PreprintMicrobiology