Dual Role of Glycosylation in Resistance to CD4-binding Site Broadly Neutralizing Antibodies
Teresa Anne Murphy, Meagan Kelly, Kai S Shimagaki, Thomas DeStefanis, Gabriel Galeotos, Myungjin Lee, Qing Wei, J Novak, Katharine J. Bar, John P. Barton, Rebecca M. Lynch
The paper shows that glycan N276 at Env affects resistance to VRC01-class bNAbs, with its impact varying based on Env, bNAb, and producer cell glycosylation.
Journal of Virology · Apr 3, 2026Peer-reviewedImmunology