Myungjin Lee

Mapping Parkinson's Disease Progression through Deep Plasma Proteomics and Functional Genomics

This study identifies plasma protein biomarkers and mechanistic pathways in Parkinson's disease using deep proteomics and functional genomics.

Dual Role of Glycosylation in Resistance to CD4-binding Site Broadly Neutralizing Antibodies

The paper shows that glycan N276 at Env affects resistance to VRC01-class bNAbs, with its impact varying based on Env, bNAb, and producer cell glycosylation.

GLYCO-2: a Tool to Quantify Glycan Shielding of Glycosylated Proteins with Improved Data Processing and Computation Speed

GLYCO-2 improves computational efficiency for quantifying glycan shielding of glycoproteins, revealing increased shielding in influenza HA proteins over time.

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state

This study identifies an occluded-intermediate state in the HIV-1 Env trimer transition pathway using molecular dynamics and smFRET, revealing new structural features and antibody recognition.