Author

J. A. Ainsa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 4 Approach:deep learning· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Gomara-Lomero· 3 shared S. Ramon-Garcia· 3 shared A. I. Lopez-Calleja· 2 shared A. Rezusta· 2 shared C. Scribani· 1 shared E. Anoz-Carbonell· 1 shared F. Cutruzzola· 1 shared F. R. Liberati· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

M. Gomara-Lomero

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Merging Multi-OMICs with Proteome Integral Solubility Alteration Unveils Antibiotic Mode of Action

R. Maity, X. Zhang, F. R. Liberati, C. Scribani, F. Cutruzzola, S. Rinaldo, M. Gaetani, J. A. Ainsa, J. Sancho

This study introduces a multi-omics method to distinguish target-specific and off-target effects of antibiotics using proteome solubility in Helicobacter pylori.

bioRxiv · Sep 7, 2023Microbiology

Repurposing azithromycin in combination with last-line fosfomycin, colistin and tigecycline against Multi-Drug Resistant Klebsiella pneumoniae

M. Gomara-Lomero, A. I. Lopez-Calleja, A. Rezusta, J. A. Ainsa, S. Ramon-Garcia

This study evaluates azithromycin combinations with last-line antibiotics against MDR/XDR K. pneumoniae, finding synergistic effects in all tested combinations.

bioRxiv · Jul 3, 2022 · PreprintMicrobiology

Zidovudine multi-combos with last-line fosfomycin, ceftazidime-avibactam, colistin and tigecycline against Multi-Drug Resistant Klebsiella pneumoniae

M. Gomara-Lomero, A. I. Lopez-Calleja, A. Rezusta, J. A. Ainsa, S. Ramon-Garcia

This study evaluates zidovudine-based combinations with last-line antibiotics against MDR K. pneumoniae, finding synergistic effects and potent bactericidal activity in vitro.

bioRxiv · May 17, 2022 · PreprintMicrobiology

Novel synergistic combinations of last-line antibiotics and FDA-approved drugs against Klebsiella pneumoniae revealed by in vitro synergy screenings

M. Gomara-Lomero, J. A. Ainsa, S. Ramon-Garcia

bioRxiv · May 16, 2022 · PreprintMicrobiology

In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target

I. Lans, E. Anoz-Carbonell, K. Palacio-Rodriguez, J. A. Ainsa, M. Medina, P. Cossio

The paper develops an integrative virtual screening protocol to identify ligands for FAD synthase, validates five inhibitors against bacterial pathogens, and demonstrates its cost-effectiveness for drug discovery.

PLOS Computational Biology · Aug 14, 2020Peer-reviewedBiophysics