FIBRIN POLYMER ON THE SURFACE OF BIOMATERIAL IMPLANTS DRIVES THE FOREIGN BODY REACTION
A. Balabiyev, N. P. Podolnikova, J. A. Kilbourne, D. P. Baluch, D. Lowry, A. Zare, R. Ros, M. J. Flick, T. P. Ugarova
This study identifies fibrin polymer as the key biological substrate driving the foreign body reaction by showing reduced macrophage fusion and fibrous capsule formation in fibrinogen-deficient mice.
bioRxiv · Feb 16, 2021Immunology