Regulation of Neuroendocrine Plasticity by the RNA-Binding Protein ZFP36L1
H.-Y. Chen, Y. T. Durmaz, Y. Li, A. H. Sabet, A. Vajdi, T. Denize, E. Walton, J. G. Doench, N. R. Mahadevan, J. A. Losman, D. A. Barbie, M. Y. Tolstorukov, C. M. Rudin, T. Sen, S. Signoretti, M. Oser
This study identifies ZFP36L1 as an LSD1 target gene that regulates neuroendocrine plasticity in SCLC by destabilizing mRNAs of lineage transcription factors.
bioRxiv · Oct 22, 2021Cancer Biology