Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis
S. C. Schwager, L. A. Hapach, C. M. Carlson, J. A. Mosier, T. J. McArdle, W. Wang, A. L. Jayathilake, F. Bordeleau, M. A. Antonyak, R. A. Cerione, C. A. Reinhart-King
This study shows weakly migratory breast cancer cells use microvesicle-Tg2 to activate fibroblasts, promoting metastasis through tumor stiffening and fibroblast activation.
bioRxiv · Oct 27, 2021Cancer Biology