R. A. Cerione

This study shows PTEN loss increases EV biogenesis and PD-L1 cargo in glioma cells via PI3K signaling, enhancing immunosuppression.

This study shows that filament formation by glutaminase enzymes GAC and GLS2 is directly linked to their catalytic activity and presents cryo-EM structures revealing the conformational changes essential for glutaminolysis in cancer.

This study identifies a multiprotein complex, DockTOR, that sustains AKT and mTOR/S6K activity in cancer cells under stress, enabling survival through a mechanism independent of growth factor signaling.

The paper identifies NAMPT-containing microvesicles as mediators of radiation resistance in glioma stem cells through proteomic analysis.

This study shows weakly migratory breast cancer cells use microvesicle-Tg2 to activate fibroblasts, promoting metastasis through tumor stiffening and fibroblast activation.

The paper investigates the mechanism of action of GAC inhibitors using crystallography and computational models, revealing conformational differences that affect potency.

The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.

The paper reports a cryoEM structure of the PDE6 complex with GTP-bound transducin, revealing its catalytic mechanism and conformational dynamics.