The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks
R. K. R. marreddy, J. A. Picker, G. Phelps, R. T. Powell, P. Cherian, J. Bowling, C. C. Stephan, R. Lee, J. G. Hurdle
This paper identifies enoxolone, a licorice metabolite, as an inhibitor of C. difficile toxin production by disrupting metabolic pathways, showing improved efficacy when combined with vancomycin in a mouse model.
bioRxiv · Apr 20, 2022 · PreprintMicrobiology