Author

R. K. R. marreddy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. G. Hurdle· 2 shared A. O. Olaitan· 1 shared C. C. Stephan· 1 shared G. Phelps· 1 shared J. A. Picker· 1 shared J. Bowling· 1 shared J. May· 1 shared M. Dong· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

J. G. Hurdle

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Author profile →

2 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 20, 2022

The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks

R. K. R. marreddy, J. A. Picker, G. Phelps…·J. G. Hurdle

This paper identifies enoxolone, a licorice metabolite, as an inhibitor of C. difficile toxin production by disrupting metabolic pathways, showing improved efficacy when combined with vancomycin in a mouse model.

DOI 10.1101/2022.04.20.488993

mouseproteomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintJul 27, 2020

Ebselen Exhibits Antimicrobial Activity Against Clostridioides difficile By Disrupting Redox Associated Metabolism

R. K. R. Marreddy, A. O. Olaitan, J. May…·J. G. Hurdle

This study shows ebselen inhibits C. difficile by disrupting redox metabolism and toxin production, with bactericidal effects beyond its previously known anti-toxin activity.

DOI 10.1101/2020.07.27.224337

C. elegansbulk RNA-seq

𝕏 PostBluesky