Circadian Clock Core Component Bmal1 Dictates Cell Cycle Rhythm of Proliferating Hepatocytes during Liver Regeneration
H. Jiang, V. Garcia, J. A. Yanum, J. Lee, G. Dai
This study shows that Bmal1 regulates the rhythmic cell cycle progression and lipid accumulation in hepatocytes during liver regeneration, with disruptions in Bmal1 leading to delayed DNA synthesis, loss of mitotic oscillation, and altered redox state.
bioRxiv · Aug 11, 2021Pathology