G. Dai

3D Brain Vascular Niche Model Captures Invasive Behavior and Gene Signatures of Glioblastoma

This paper develops a 3D brain vascular niche model to study GBM invasion and gene signatures, revealing glia-vascular contact influences transcriptional adaptation and poor prognosis.

Voltage Sensor Conformations Induced by LQTS-associated Mutations in hERG Potassium Channels

The paper identifies intermediate voltage-sensor conformations in hERG channels caused by LQTS-associated mutations using FLIM, tmFRET, and MD simulations.

Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons

The paper shows that lipid nanodomains modulate HCN channels in DRG neurons, affecting pain signaling and neuronal firing.

Direct Regulation of the Voltage Sensor of HCN Channels by Membrane Lipid Compartmentalization

The paper investigates how membrane lipid domains affect the voltage sensor of HCN channels using FLIM and FRET, finding that lipid compartmentalization influences channel activity and contributes to disease.

Maternal Hepatocytes Heterogeneously and Dynamically Exhibit Developmental Phenotypes Partially via YAP1 during Pregnancy

This study shows maternal hepatocytes acquire developmental phenotypes during pregnancy, partially via YAP1, and maintain metabolic zonation independently of the Hippo/YAP1 pathway.

A GSVA based gene set synergizing with CD4+T cell bearing harmful factors yield risk signals in HBV related diseases via amalgamation of artificial intelligence

The paper uses GSVA and AI to identify a gene set and immune signals associated with poor prognosis in HBV-related diseases.

ITRAQ-based quantitative proteomic analysis of japonica rice seedling during cold stress

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

Circadian Clock Core Component Bmal1 Dictates Cell Cycle Rhythm of Proliferating Hepatocytes during Liver Regeneration

This study shows that Bmal1 regulates the rhythmic cell cycle progression and lipid accumulation in hepatocytes during liver regeneration, with disruptions in Bmal1 leading to delayed DNA synthesis, loss of mitotic oscillation, and altered redox state.

GDF8 Contributes to the Adverse Effects of Liver Injury on Skeletal Muscle Homeostasis and Regeneration

This study identifies GDF8 as a mediator of liver-muscle crosstalk that contributes to muscle atrophy in liver disease and shows that targeting GDF8 can reverse these effects.

Activin B Promotes the Initiation and Progression of Liver Fibrosis

This study shows activin B promotes liver fibrosis initiation and progression by acting on hepatocytes and hepatic stellate cells, and its neutralization prevents and regresses fibrosis in mice.

Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy

This study shows that Ascl1 activation in maternal liver during pregnancy supports healthy pregnancy outcomes by coordinating maternal organ adaptations and placental growth.

The Lack of Nrf2 Causes Hepatocyte Dedifferentiation and Reduced Albumin Production in an Experimental Extrahepatic Cholestasis Model

This study shows that Nrf2 deficiency leads to hepatocyte dedifferentiation and reduced albumin production in a cholestasis model.

New exon ignites accelerated evolution of placental gene Nrk in the ancestral lineage of eutherians

The paper identifies accelerated evolution in the Nrk gene's exons in eutherian mammals, suggesting a new exon ignited positive selection linked to placental development.

NONCANONICAL ELECTROMECHANICAL COUPLING MECHANISM OF AN HCN CHANNEL

The paper investigates the structural rearrangements in spHCN channels during activation and inactivation, revealing a noncanonical electromechanical coupling mechanism involving the A helix and cAMP binding.

Recruitment of Neuronal KCNQ2/3 Channels to Membrane Microdomains Depends on Palmitoylation of Alzheimer's Disease-Related Protein BACE1

This study shows that BACE1 palmitoylation is required for recruiting KCNQ2/3 channels to lipid rafts, as demonstrated by FRET experiments and cholesterol-disrupting treatments.

High-Resolution Tomographic Analysis of in vitro 3D Glioblastoma Tumor Model under Long-Term Drug Treatment

This paper develops an in vitro 3D GBM model and a mesoscopic imaging system to monitor tumor growth and drug response over 70 days.

The HCN Channel Voltage Sensor Undergoes A Large Downward Motion During Hyperpolarization

This study measures the movement of the HCN channel's S4 helix during hyperpolarization using tmFRET and reveals a significant downward motion and tilting, providing insights into reverse gating mechanisms.