J. Aguilan

Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model

This study shows that 3D liver spheroids can model chromatin dynamics and reversible histone acetylation, with cells recovering their original transcriptome and proteome after histone deacetylase inhibitor treatment.

Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutation

The paper uses locus-specific proteomics to identify proteins associated with the V region chromatin in SHM and validates their function using a Dot1L inhibitor.