Author

J. Ainscough

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

D. Coverley· 2 shared S. Sofi· 2 shared A. A. Antson· 1 shared A. Alati· 1 shared A. S. Mason· 1 shared C. Hirst· 1 shared C. Scoynes· 1 shared E. Lopez de Alba· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

D. Coverley

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2 papers

Recent·Most cited

Dominant CIZ1 fragments drive epigenetic instability and are expressed in early stage cancers

G. Turvey, E. Lopez de Alba, E. Stewart, L. Byrom, H. Cook, S. Sofi, A. Alati, J. Ainscough, A. S. Mason, A. A. Antson, D. Coverley

This study identifies that elevated CIZ1 anchor domain fragments in early stage cancers disrupt SMACs, leading to epigenetic instability by destabilizing PRC1-dependent histone modifications.

bioRxiv · Sep 22, 2023 · PreprintCell Biology

A polyglutamine domain is required for de novo CIZ1 assembly formation at the inactive X chromosome

S. Sofi, L. Williamson, G. L. Turvey, C. Scoynes, C. Hirst, J. Godwin, N. Brockdorff, J. Ainscough, D. Coverley

The paper shows that a polyglutamine domain in CIZ1 is required for forming de novo assemblies at the inactive X chromosome, mediated by interactions with Xist RNA.

bioRxiv · Nov 10, 2020Cell Biology