E. Stewart

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage

This study shows that metabolic enzymes act as autophagy receptors in plants to degrade defense executors during viral infection, revealing autophagy as a tolerance pathway rather than an antiviral defense.

Germinal center BCR maturation in appendicitis reveals a role for antigen-specific adaptive immune responses during disease

This study identifies antigen-dependent B cell activation and microbial dysbiosis in appendicitis, linking immune and microbial factors to disease pathology.

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma

This study identifies therapy-resistant and tumor-acquired cell states in pediatric rhabdomyosarcoma using single-cell RNA sequencing.

Dominant CIZ1 fragments drive epigenetic instability and are expressed in early stage cancers

This study identifies that elevated CIZ1 anchor domain fragments in early stage cancers disrupt SMACs, leading to epigenetic instability by destabilizing PRC1-dependent histone modifications.

A genome-wide cytotoxicity screen of Cluster F1 mycobacteriophage Girr reveals novel inhibitors of Mycobacterium smegmatis growth

This study screens phage genes to identify inhibitors of Mycobacterium smegmatis growth, finding 29 toxic genes, 12 of which are novel antimicrobial proteins.

A bench-top dark-root device built with LEGO bricks enables a non-invasive plant root development analysis in soil conditions mirroring nature

The paper introduces a LEGO-based dark-root device for non-invasive root analysis in soil, showing root illumination affects proteome and phenotype in barley.

The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

Microtubules Promote the Non-cell Autonomy of MicroRNAs by Inhibiting their Cytoplasmic Loading into ARGONAUTE1 in Arabidopsis

The paper shows that microtubules inhibit miR165/6 loading into AGO1 in the cytoplasm, enabling its non-cell autonomous movement in Arabidopsis roots.

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

MYCN Amplification and ATRX Mutations are Incompatible in Neuroblastoma

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.