Mammalian stringent-like response mediated by the cytosolic NADPH phosphatase MESH1
C.-K. C. Ding, J. Rose, J. Wu, T. Sun, K.-Y. Chen, P.-H. Chen, E. Xu, S. Tian, J. Akinwuntan, Z. Guan, P. Zhou, J.-T. A. Chi
This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.
bioRxiv · May 17, 2018Biochemistry