J.-T. A. Chi

NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation

This paper shows NINJ1 protects cancer cells from ferroptosis by interacting with xCT antiporter and modulating CoA and GSH levels.

O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

This study shows that O-GlcNAcylation regulates NF-L assembly and function, and CMT mutations disrupt this process, linking glycosylation defects to neurodegeneration.

Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveal the potential role of ketogenesis to slow tumor growth: A secondary analysis of the CAPS2 diet trial

This paper analyzes serum metabolomics from a low-carbohydrate diet trial in prostate cancer patients to identify metabolic changes associated with slower tumor growth.

Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer

This study shows that STK3, typically a tumor suppressor, promotes prostate cancer growth and identifies STK3 inhibitors with therapeutic potential.

The effects of low-carbohydrate diets on the metabolic response to androgen-deprivation therapy in prostate cancer

This study investigates how low-carbohydrate diets affect metabolic changes in prostate cancer patients undergoing androgen deprivation therapy, finding that the diet reverses some adverse metabolic effects while slightly lowering androgen levels.

Heterogeneous timing of asexual cycles in Plasmodium falciparum quantified by extended time-lapse microscopy

This study quantifies the heterogeneous timing of asexual cycles in Plasmodium falciparum using time-lapse microscopy and finds that unsynchronized cultures have a bimodal burst time distribution and that artificial synchronization does not fundamentally alter cycle dynamics.

G9a Promotes Breast Cancer Recurrence Through Repression of a Pro-inflammatory Program

This study shows that G9a promotes breast cancer recurrence by repressing pro-inflammatory genes, leading to necroptosis when inhibited.

Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells and protects against liver fibrosis

This study shows that inhibiting xCT/SLC7A11 induces ferroptosis in myofibroblastic hepatic stellate cells, reducing liver fibrosis without worsening liver injury.

Mammalian stringent-like response mediated by the cytosolic NADPH phosphatase MESH1

This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.