The variant Senescence-Associated-Secretory-Phenotype induced by centrosome amplification constitutes a pathway that activates Hypoxia-Inducible-Factor-1α.
S. K. Wu, J. Ariffin, R. Picone
The paper shows centrosome amplification induces a variant SASP pathway that activates HIF-1α through Rac and ROS, promoting paracrine invasion but with no DNA damage or NF-κB activation.
bioRxiv · Dec 8, 2020Cell Biology