Author

S. K. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. M. Griffin· 1 shared A. M. Johnson· 1 shared A. Yap· 1 shared B. C. Low· 1 shared C. B.-X. Huang· 1 shared C. Barrington· 1 shared C. T. Lim· 1 shared C. Z. Ho· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. M. Griffin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multiscale mechanisms driving tissue rupture by invading cells

S. K. Wu, F. Sun, C. Z. Ho, Y. Lou, C. B.-X. Huang, M. H. Nai, J. Xiao, M. Shagirov, J. F. L. Chin, D. Lim, S. Verma, D. S. Tan, P. Marcq, A. Yap, C. T. Lim, , B. C. Low

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

bioRxiv · Sep 25, 2023Cell Biology

The variant Senescence-Associated-Secretory-Phenotype induced by centrosome amplification constitutes a pathway that activates Hypoxia-Inducible-Factor-1α.

S. K. Wu, J. Ariffin, R. Picone

The paper shows centrosome amplification induces a variant SASP pathway that activates HIF-1α through Rac and ROS, promoting paracrine invasion but with no DNA damage or NF-κB activation.

bioRxiv · Dec 8, 2020Cell Biology

RNA matchmaking remodels lncRNA structure and promotes PRC2 activity

M. M. Balas, E. W. Hartwick, C. Barrington, J. T. Roberts, S. K. Wu, R. Bettcher, A. M. Griffin, J. S. Kieft, A. M. Johnson

The paper shows that RNA matchmaking between HOTAIR and target gene RNAs relieves PRC2 inhibition, promoting its activity through structural changes and hnRNP B1-mediated interactions.

bioRxiv · Apr 13, 2020 · PreprintBiochemistry