Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with Veliparib
I. Alvarado-Cruz, M. Mahmoud, M. Khan, S. Zhao, S. Oeck, R. Meas, K. Clairmont, V. Quintana, Y. Zhu, A. Porciuncula, H. Wyatt, S. Ma, Y. Shyr, Y. Kong, P. M. LoRusso, , J. B. Sweasy
This study shows that long-term veliparib treatment leads to chromatin-bound PARP1 and upregulation of inflammatory genes in BRCA1 mutant cells, but not in BRCA1-complemented cells.
bioRxiv · Mar 8, 2020 · PreprintCancer Biology