M. Khan

The single-cell make-up of adult diffuse glioma based on the 2021 WHO classification

This paper applies a fetal neural progenitor cell classification to adult diffuse gliomas, finding distinct THY1-CD24-EGFR+ and THY1-CD24-EGFR- cell populations across IDH mutant and IDHwt gliomas.

What scRNA sequencing taught us about MGMT expression in glioblastoma

The paper uses scRNA-seq data to analyze MGMT expression in glioblastoma and finds that MGMT expression is low in methylated samples and varies in unmethylated samples, with potential implications for survival.

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

This paper shows that PPARG in osteocytes regulates bioenergetics and systemic energy metabolism in mice, independent of sclerostin levels, with sex-specific effects on mitochondrial function and insulin signaling.

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

The small iron-deficiency-induced protein OLIVIA and its relation to the bHLH transcription factor POPEYE

This study identifies OLIVIA as a small Fe deficiency-induced protein that interacts with the bHLH transcription factor POPEYE, influencing Fe homeostasis and leaf growth.

Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis

The paper identifies two non-canonical L-cysteine synthases in Mtb, CysM and CysK2, which support divergent biosynthetic pathways critical for redox stress response and survival during infection.

DENND6A couples Arl8b to a Rab34/RILP/dynein complex regulating retrograde lysosomal trafficking and autophagy

This study identifies DENND6A as a Rab34 GEF that couples with Arl8b to regulate lysosomal retrograde trafficking and autophagy.

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma

This study uses scRNA-seq to identify two distinct subsets of pathogenic Th2 cells in allergic asthma and establishes an in vitro model to study their regulation.

Patterns of speciation in a parapatric pair of Saturnia moths as revealed by Target Capture

This study uses target capture and mtDNA sequencing to resolve the phylogenetic relationships and taxonomy of two parapatric Saturnia moth species, revealing mitonuclear discordance and past introgression.

Tip of the iceberg? Three novel TOPLESS interacting effectors of the gall-inducing fungus Ustilago maydis

The paper identifies three novel effector proteins from Ustilago maydis that interact with maize TPL proteins and modulate auxin signaling, contributing to fungal virulence.

The fungal pathogen Ustilago maydis targets the maize corepressor TPL2 to modulate host transcription for tumorigenesis

This study identifies Tip6, an effector protein from Ustilago maydis, which interacts with ZmTPL2 to disrupt host transcriptional regulation and promote tumorigenesis.

Solvent based fractional biosynthesis, phytochemical analysis and biological activity of silver nanoparticles obtained from extract of Salvia moorcroftiana

This study synthesizes silver nanoparticles from Salvia moorcroftiana extracts using different solvents and evaluates their antibacterial activity against multidrug-resistant bacteria.

Unique interactions and functions of the mitochondrial small Tims in Trypanosoma brucei

This study identifies unique interactions and functional roles of small TbTims in the TbTIM17 complex of T. brucei, revealing distinct complex architectures and dynamics.

DENND2B activates Rab35 at the intercellular bridge regulating cytokinetic abscission and tetraploidy

This study identifies DENND2B as a Rab35 GEF that regulates cytokinetic abscission and prevents tetraploidy by modulating actin dynamics and the NoCut checkpoint.

Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.

This study shows that GsdmD in myeloid cells promotes lung cancer metastasis in mice by enhancing inflammasome activity and IL-1β release.

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury

This study shows that inhibiting BKCa channels in neonatal cardiomyocytes protects against myocardial ischemia-reperfusion injury, unlike in adult hearts where activation provides protection.

TOPLESS promotes plant immunity by repressing auxin signaling and is targeted by the fungal effector Naked1

The paper shows that the fungal effector Naked1 manipulates plant TOPLESS proteins to suppress immunity by enhancing auxin signaling, and engineered variants of Naked1 can induce resistance.

Gasdermin D mediates inflammation-induced defects in reverse cholesterol transport and promotes atherosclerosis.

Proteomic insight into soybean response to flooding stress reveals changes in basic energy metabolism and cell wall modifications

This study uses proteomic analysis to identify changes in soybean response to flooding stress, revealing shifts in energy metabolism and cell wall modifications.

Acquired fluoroquinolone resistance genes in corneal isolates of Pseudomonas aeruginosa

The paper investigates the prevalence of acquired fluoroquinolone resistance genes in Pseudomonas aeruginosa corneal isolates and their association with antibiotic susceptibility.

Changes to the resistome of Pseudomonas aeruginosa clone ST308 associated with corneal infection over time

This study compares the resistomes of Pseudomonas aeruginosa clone ST308 isolates from 1997 and 2018, finding increased resistance genes and mobile element-associated resistance in recent isolates.

Computational vaccinology based development of multi-epitope subunit vaccine for protection against the Norovirus infections

This study develops a multi-epitope subunit vaccine against Norovirus using computational vaccinology, selecting antigenic epitopes and modeling the vaccine structure for potential experimental validation.

Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with Veliparib

This study shows that long-term veliparib treatment leads to chromatin-bound PARP1 and upregulation of inflammatory genes in BRCA1 mutant cells, but not in BRCA1-complemented cells.

Human iPS Cells Derived Skeletal Muscle Progenitor Cells Promote Myoangiogenesis and Restore Dystrophin in Duchenne Muscular Dystrophic Mice

This study generates muscle progenitor cells from hiPSCs using givinostat and shows they restore dystrophin and promote myoangiogenesis in DMD mice.

A suppressor of axillary meristem maturation promotes longevity in flowering plants

This study identifies AHL15 as a suppressor of axillary meristem maturation that promotes plant longevity in Arabidopsis and tobacco by extending lifespan through delayed meristem maturation.

Brucella suppress innate immunity by down-regulating STING expression in macrophages

This study shows Brucella suppresses STING expression via miR-24 to evade innate immunity and establish chronic infection.

Brucella Peptide Cross-Reactive MHC I Presentation Activates SIINFEKL-Specific TCR Expressing T Cells

The paper shows that Brucella peptides can activate SIINFEKL-specific TCR-expressing T cells through cross-reactivity, suggesting immune evasion and potential autoimmunity.