Comparative analysis of PknB inhibitors for reactivity and toxicity
N. Wlodarchak, J. Beczkiewicz, S. Seitz, Z. Ye, J. Feltenberger, J. M. Davis, R. T. Striker
This study evaluates the reactivity and toxicity of a PknB inhibitor, YH-8, finding high reactivity with thiolating agents, toxicity in zebrafish, and limited activity against non-tubercular mycobacteria.
bioRxiv · Sep 20, 2018 · PreprintMicrobiology