Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicity
Z. Hilbert, K. Chung, J. Bednarek, M. Schwiesow, J. C. S. Brown, N. C. Elde
The paper identifies a point mutation in adenylate cyclase that improves fungal growth in macrophages but reduces disease severity in mice.
bioRxiv · Sep 27, 2022 · PreprintMicrobiology